AI-assisted discovery for systematic reviewers
Find the gaps in evidence synthesis
Describe a clinical area. SynthGap searches 33 million PubMed articles, checks each candidate against 500,000+ systematic reviews, and proposes novel meta-analysis topics — with the primary studies to back them.
Try
Step 1
Search the literature
We retrieve the studies closest to your topic from a 33-million-article PubMed index.
Step 2
Check what's covered
Each candidate is cross-checked against 500,000+ systematic reviews to find where synthesis is missing or outdated.
Step 3
Get novel topics
Receive specific, justified topics with a PICO framework and the primary studies each would include.
Analyzing
Starting…
Searches run
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Papers examined
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Clusters mapped
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Retrieval activity
The 3 most similar papers from each search, as the agent works
Literature map
clusters by rank
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higher
Size
studies per cluster
Rank = recency × cohesion · scroll to zoom · drag to pan · click a cluster